What's New
[New Products] Trapping Reagents
2023.09.08
The trapping reagents optimized according to metabolic system to be assessed by Prof. Tomoyuki Ohe’s group (Faculty of Pharmaceutical Sciences, Keio University) are now available.
You can select the suited reagent for your assessment.
CysGlu-Dan
CysGlu-Dan can be used in the replacement of Dansyl-GSH as a detection reagent.
While Dansyl-GSH can only detect reactive metabolites with “soft” electrophilicity, CysGlu-Dan can also detect reactive metabolites with “hard” electrophilicity.
Dap-Dan
Acyl glucuronides are trapped with Dap-Dan and can be detected as acylation and/or glycation adducts of Dap-Dan.
Cys-Dan
Reactive acyl-CoAs are trapped with Cys-Dan and can be detected as the adduct.
To find product information such as size, specifications, pricing, and availability, click on the structural formula, code or product name.
For the detection of…
| CYP-dependent reactive metabolites (Detectable both “hard” and “soft” reactive metabolites) |
R00846 CysGlu-Dan |
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| Reactive acyl glucuronides | R00845 Dap-Dan |
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| Reactive acyl-CoA | R00847 Cys-Dan |
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| CYP-dependent reactive metabolites (Detectable only “soft” reactive metabolites) |
R02168 Dansyl-GSH |
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[References]
1. Shibazaki C. Ohe T. Takahashi K. Nakamura S. Mashino T. Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites. Drug Metab. Pharmacokinet. 2021, 39, No. 100386.
2. Shibazaki C. MashitaO. Takahashi K. Nakamura S. Mashino T. Ohe T. Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides. Chem. Res. Toxicol. 2021, 34, 2343-2352.
3. Shibazaki C. Mashino T. Ohe T. Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates. Drug Metab. Pharmacokinet. 2023, 52, No. 100509.